SLU-PP-332

Description

SLU-PP-332 is a synthetic small-molecule research compound studied for its role as an estrogen-related receptor (ERR) agonist, with published work describing it as a pan-ERR agonist showing the greatest potency at ERRα. In laboratory settings, it is primarily investigated for relevance to mitochondrial function, oxidative metabolism, skeletal muscle energy pathways, and broader exercise-mimetic and metabolic research models. Preclinical studies in mice have linked SLU-PP-332 to activation of aerobic exercise-associated gene programs, enhanced endurance-related adaptations, increased energy expenditure, and improved metabolic parameters in obesity and metabolic syndrome models, which is why it has attracted growing interest in experimental work focused on metabolic regulation, fatty-acid oxidation, and cellular bioenergetics. As of current published reporting, its evidence base remains preclinical, with newer 2026 work focusing on chemical optimization and oral-activity efforts rather than established human use.